Chrisp C E, Suckow M A, Fayer R, Arrowood M J, Healey M C, Sterling C R
Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor 48109.
J Protozool. 1992 May-Jun;39(3):406-9. doi: 10.1111/j.1550-7408.1992.tb01471.x.
Oocysts of a Cryptosporidium isolate from guinea pigs were not infectious for adult mice, but were infectious for two of three newborn calves and for suckling mice. However, oocysts isolated from calves or mice infected with guinea pig Cryptosporidium were not infectious for guinea pigs. Four isolates of C. parvum from calves were incapable of infecting weanling guinea pigs. Microscopic examination of tissue from the colon and cecum of suckling guinea pigs inoculated with C. parvum revealed sparse infection of some pups. These host range studies and previously described differences in 125I-labeled oocyst surface protein profiles between Cryptosporidium sp. from guinea pigs and C. parvum suggest they are distinct species. We propose the name Cryptosporidium wrairi be retained. Studies with monoclonal antibodies indicate that C. wrairi and C. parvum are antigenically related.
从豚鼠分离出的隐孢子虫的卵囊对成年小鼠无感染性，但对三头新生小牛中的两头以及乳鼠有感染性。然而，从感染了豚鼠隐孢子虫的小牛或小鼠中分离出的卵囊对豚鼠无感染性。从牛分离出的四株微小隐孢子虫无法感染断奶豚鼠。对接种微小隐孢子虫的乳豚鼠的结肠和盲肠组织进行显微镜检查发现，一些幼崽有稀疏感染。这些宿主范围研究以及先前描述的豚鼠隐孢子虫与微小隐孢子虫之间125I标记的卵囊表面蛋白谱的差异表明它们是不同的物种。我们建议保留Cryptosporidium wrairi这个名称。单克隆抗体研究表明，wrairi隐孢子虫和微小隐孢子虫在抗原上相关。
