BARTLET A L
Br J Pharmacol Chemother. 1962 Jun;18(3):475-89. doi: 10.1111/j.1476-5381.1962.tb01169.x.
In anaesthetized cats 3-phenoxypropylguanidine caused a contracture of the nictitating membrane, a dilatation of the pupil and a fall followed by a rise in the arterial blood pressure. In spinal preparations of cats the initial fall in blood pressure was usually absent and the rise in blood pressure subsided to a steady level, which was about 10 mm Hg above the initial pressure. The pressor action and the contracture of the nictitating membrane were inhibited by phenoxybenzamine and by previous treatment with reserpine, but were not abolished by adrenalectomy and bretylium. 3-Phenoxypropylguanidine potentiated the actions of adrenaline and noradrenaline, increased the blood glucose concentration of the rabbit and decreased the appetite of the cat. The action of tyramine on the cardiovascular system was inhibited by 3-phenoxypropylguanidine, but the stimulant action of tyramine on the nictitating membrane of the cat was not abolished by this substance. Although 3-phenoxypropylguanidine produced a local anaesthesia of long duration in guinea-pig skin, it failed to anaesthetize the rabbit cornea. The responses to stimulation of the preganglionic cervical sympathetic nerve of the cat and the great auricular nerve of the rabbit ear were not abolished by 3-phenoxypropylguanidine; neither did this substance abolish the nicotinic action of acetylcholine in atropinized cats. Contractions of the rat fundus to tryptamine and 5-hydroxytryptamine were antagonized by 3-phenoxypropylguanidine, but were potentiated by cocaine.
在麻醉猫中，3-苯氧基丙基胍可引起瞬膜挛缩、瞳孔散大以及动脉血压先下降后上升。在猫的脊髓制备标本中，通常不会出现最初的血压下降，且血压上升会降至稳定水平，该水平比初始压力高约10毫米汞柱。苯氧苄胺和预先用利血平处理可抑制3-苯氧基丙基胍的升压作用和瞬膜挛缩，但肾上腺切除术和溴苄铵不能消除这些作用。3-苯氧基丙基胍可增强肾上腺素和去甲肾上腺素的作用，增加兔的血糖浓度，并降低猫的食欲。3-苯氧基丙基胍可抑制酪胺对心血管系统的作用，但该物质不能消除酪胺对猫瞬膜的兴奋作用。尽管3-苯氧基丙基胍可在豚鼠皮肤产生长时间的局部麻醉，但它不能麻醉兔角膜。3-苯氧基丙基胍不会消除对猫颈交感神经节前神经和兔耳大耳神经刺激的反应；该物质也不会消除阿托品化猫中乙酰胆碱的烟碱样作用。3-苯氧基丙基胍可拮抗大鼠胃底对色胺和5-羟色胺的收缩作用，但可增强可卡因的作用。
