Griffin D, Fairman N, Coursin D, Rawsthorne L, Grossman J E
Department of Anesthesiology, University of Wisconsin, Madison.
Chest. 1992 Aug;102(2):510-4. doi: 10.1378/chest.102.2.510.
Acute myopathy in patients being treated for severe asthma has been recognized with increasing frequency since first being described in 1977. We report three patients treated for status asthmaticus who developed severe generalized weakness. Electrophysiologic studies and muscle biopsy revealed evidence of muscle destruction. Each of these patients was treated with high-dose corticosteroids and underwent prolonged neuromuscular blockade with a steroidal muscle relaxant. A review of the literature revealed 15 similar cases. We postulate that the combined effects of corticosteroids and muscle relaxants on the muscle cell may be responsible for this myopathy. Patients treated with corticosteroids and NMBs should be carefully monitored for the development of myopathy.
自1977年首次被描述以来，接受重症哮喘治疗的患者中急性肌病的发生率日益增加。我们报告了3例接受哮喘持续状态治疗后出现严重全身无力的患者。电生理研究和肌肉活检显示有肌肉破坏的证据。这些患者均接受了大剂量皮质类固醇治疗，并使用甾体类肌肉松弛剂进行了长时间的神经肌肉阻滞。文献回顾发现了15例类似病例。我们推测皮质类固醇和肌肉松弛剂对肌肉细胞的联合作用可能是导致这种肌病的原因。接受皮质类固醇和神经肌肉阻滞剂治疗的患者应密切监测肌病的发生。
