• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Increased level of dihydrofolic reductase in leucocytes of patients treated with amethopterin.

作者信息

BERTINO J R, DONOHUE D R, GABRIO B W, SILBER R, ALENTY A, MEYER M, HUENNEKENS F M

出版信息

Nature. 1962 Jan 13;193:140-2. doi: 10.1038/193140a0.

DOI:10.1038/193140a0
PMID:13868435
Abstract
摘要

相似文献

1
Increased level of dihydrofolic reductase in leucocytes of patients treated with amethopterin.接受氨甲蝶呤治疗的患者白细胞中二氢叶酸还原酶水平升高。
Nature. 1962 Jan 13;193:140-2. doi: 10.1038/193140a0.
2
Inhibition of dihydrofolic reductase by aminopterin and amethopterin.氨蝶呤和甲氨蝶呤对二氢叶酸还原酶的抑制作用。
Proc Soc Exp Biol Med. 1958 Feb;97(2):429-31. doi: 10.3181/00379727-97-23764.
3
The association of increased dihydrofolate reductase with amethopterin resistance in mouse leukemia.小鼠白血病中增加的二氢叶酸还原酶与氨甲蝶呤抗性的关联。
Cancer Res. 1962 Jun;22:600-6.
4
Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.培养的哺乳动物细胞中叶酸还原酶与氨甲蝶呤抗性的关系。
J Biol Chem. 1961 Mar;236:952-8.
5
Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells.
Biochem Pharmacol. 1961 Jul;7:75-7. doi: 10.1016/0006-2952(61)90128-9.
6
FURTHER OBSERVATIONS OF THE BINDING AND INHIBITION OF DIHYDROFOLIC REDUCTASE BY FOLIC ACID ANTAGONISTS.叶酸拮抗剂对二氢叶酸还原酶的结合与抑制作用的进一步观察
Biochem Pharmacol. 1964 May;13:731-42. doi: 10.1016/0006-2952(64)90009-7.
7
Studies on the folic acid vitamins. IV. The persistence of amethopterin in mammalian tissues.叶酸维生素的研究。IV. 氨甲蝶呤在哺乳动物组织中的持久性。
Cancer. 1960 Mar-Apr;13:236-40. doi: 10.1002/1097-0142(196003/04)13:2<236::aid-cncr2820130205>3.0.co;2-r.
8
Studies on the folic acid vitamins. VI. The effect of amethopterin on erythropoiesis in man.叶酸维生素的研究。VI. 氨甲蝶呤对人体红细胞生成的影响。
Cancer. 1960 Mar-Apr;13:245-9. doi: 10.1002/1097-0142(196003/04)13:2<245::aid-cncr2820130207>3.0.co;2-n.
9
On the site of action of amethopterin.
Science. 1961 Nov 3;134(3488):1421.
10
Chemical changes in the tissues of leukemic mice. II. The effects of amethopterin.白血病小鼠组织中的化学变化。II. 氨甲蝶呤的作用。
Exp Med Surg. 1961;19:251-7.

引用本文的文献

1
Regulatory mechanisms of one-carbon metabolism enzymes.一碳代谢酶的调控机制。
J Biol Chem. 2023 Dec;299(12):105457. doi: 10.1016/j.jbc.2023.105457. Epub 2023 Nov 9.
2
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.环氯胍及其类似物可有效靶向癌细胞中的二氢叶酸还原酶以发挥抗癌活性。
Metabolites. 2023 Jan 19;13(2):151. doi: 10.3390/metabo13020151.
3
Methotrexate-Induced Liver Injury Is Associated with Oxidative Stress, Impaired Mitochondrial Respiration, and Endoplasmic Reticulum Stress In Vitro.
甲氨蝶呤诱导的肝损伤与氧化应激、线粒体呼吸功能障碍和内质网应激有关。
Int J Mol Sci. 2022 Dec 1;23(23):15116. doi: 10.3390/ijms232315116.
4
Nuclear Folate Metabolism.核叶酸代谢。
Annu Rev Nutr. 2018 Aug 21;38:219-243. doi: 10.1146/annurev-nutr-071714-034441.
5
Targeting nuclear thymidylate biosynthesis.靶向细胞核胸苷酸生物合成
Mol Aspects Med. 2017 Feb;53:48-56. doi: 10.1016/j.mam.2016.11.005. Epub 2016 Nov 19.
6
Translational modulation of proteins expressed from bicistronic vectors.双顺反子载体表达蛋白的翻译调控。
Mol Imaging. 2009 Dec;8(6):305-18.
7
Species-specific differences in translational regulation of dihydrofolate reductase.二氢叶酸还原酶翻译调控中的物种特异性差异。
Mol Pharmacol. 2009 Oct;76(4):723-33. doi: 10.1124/mol.109.055772. Epub 2009 Jul 1.
8
THE "INDUCTION" OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN.用氨甲蝶呤治疗的患者白细胞和红细胞中二氢叶酸还原酶活性的“诱导”
J Clin Invest. 1963 Apr;42(4):466-75. doi: 10.1172/JCI104735.
9
[THE SIGNIFICANCE OF THE FOLIC ACID METABOLISM FOR THE NORMAL AND PATHOLOGICAL MATURATION OF BLOOD CELLS].[叶酸代谢对血细胞正常及病理成熟的意义]
Klin Wochenschr. 1963 Nov 15;41:1077-82. doi: 10.1007/BF01486507.
10
STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE.正常与白血病白细胞的研究。IV. 四氢叶酸依赖性酶系统与二氢叶酸还原酶
J Clin Invest. 1963 Dec;42(12):1899-907. doi: 10.1172/JCI104875.