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健康与疾病状态下的脑脊液蛋白质组分

Cerebrospinal fluid protein fractions in health and disease.

作者信息

BRACKENRIDGE C J

出版信息

J Clin Pathol. 1962 May;15(3):206-10. doi: 10.1136/jcp.15.3.206.

DOI:10.1136/jcp.15.3.206
PMID:13872289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC480383/
Abstract

Samples of lumbar cerebrospinal fluid from 20 healthy subjects and 20 patients with a variety of neurological disorders have been subjected to cellulose acetate electrophoresis and quantitative analyses carried out on the seven separated protein fractions. Normal percentage and absolute concentration limits for each fraction have been determined and compared with previous reports. It is concluded that absolute values are more valuable than percentage values in the discrimination of disease from health, but that the mechanisms governing protein abnormalities are difficult to ascertain from spinal fluid electrophoresis alone.

摘要

对20名健康受试者和20名患有各种神经系统疾病的患者的腰椎脑脊液样本进行了醋酸纤维素电泳,并对七个分离的蛋白质组分进行了定量分析。已确定每个组分的正常百分比和绝对浓度限值,并与先前的报告进行了比较。得出的结论是,在区分疾病与健康方面,绝对值比百分比值更有价值,但仅从脑脊液电泳很难确定蛋白质异常的机制。

相似文献

1
Cerebrospinal fluid protein fractions in health and disease.健康与疾病状态下的脑脊液蛋白质组分
J Clin Pathol. 1962 May;15(3):206-10. doi: 10.1136/jcp.15.3.206.
2
Electrophoresis of normal lumbar cerebrospinal fluid proteins in the African.非洲人正常腰段脑脊液蛋白质的电泳分析
Afr J Med Med Sci. 1976 Mar;5(1):19-22.
3
[The relationship between age and the cerebrospinal fluid protein profile profile of normal children. Cellulose acetate and agarose gel electrophoretic studies].
Neuropadiatrie. 1975 Nov;6(4):383-97. doi: 10.1055/s-0028-1091679.
4
[Studies on the normal concentration range of total protein and the total protein fractions of the cerebrospinal fluid by electrophoresis on cellulose acetate (author's transl)].用醋酸纤维素电泳法研究脑脊液总蛋白及其组分的正常浓度范围(作者译)
Z Klin Chem Klin Biochem. 1971 Jul;9(4):337-40.
5
[Cellulose acetate electrophoresis of cerebrospinal fluid: normal values].[脑脊液的醋酸纤维素电泳:正常值]
Arq Neuropsiquiatr. 1977 Sep;35(3):239-46.
6
Cellulose acetate electrophoresis of cerebrospinal fluid proteins with normal values of 135 persons.135例正常人脑脊液蛋白的醋酸纤维素电泳。
Chin Med J (Engl). 1980 Mar;93(3):169-72.
7
[Electrophoresis of unconcentrated cerebrospinal fluid on cellulose acetate film].
Psychiatr Neurol Med Psychol (Leipz). 1984 Dec;36(12):737-9.
8
[Electrophoresis of the cerebrospinal fluid proteins in the course of neurological disorders].[神经系统疾病过程中脑脊液蛋白质的电泳分析]
J Med Lyon. 1962 Apr 5;43:589-92.
9
[Polyacrylamide gel disc electrophoresis in the study of cerebrospinal fluid proteins in inflammatory diseases of the central nervous system Preliminary results].[聚丙烯酰胺凝胶圆盘电泳在中枢神经系统炎性疾病脑脊液蛋白质研究中的初步结果]
Quad Sclavo Diagn. 1981 Dec;17(4):465-74.
10
[Cerebrospinal fluid proteins: II. Normal values of protein fractions obtained by electrophoresis (variations related to race, sex and age)].[脑脊液蛋白质:II. 电泳法测得的蛋白质组分正常值(与种族、性别和年龄相关的变化)]
Arq Neuropsiquiatr. 1983 Mar;41(1):9-24. doi: 10.1590/s0004-282x1983000100002.

引用本文的文献

1
Adult CSF total protein upper reference limits should be age-partitioned and significantly higher than 0.45 g/L: a systematic review.成人 CSF 总蛋白的上参考值界限应按年龄分段,且显著高于 0.45g/L:一项系统评价。
J Neurol. 2019 Mar;266(3):616-624. doi: 10.1007/s00415-018-09174-z. Epub 2019 Jan 8.
2
Estimation of cerebrospinal fluid protein.脑脊液蛋白质的测定
J Clin Pathol. 1968 Jul;21(4):518-20. doi: 10.1136/jcp.21.4.518.
3
[Total protein levels in lumbar cerebrospinal fluid of normal subjects (author's transl)].正常受试者腰椎脑脊液中的总蛋白水平(作者译)
Klin Wochenschr. 1973 Aug 15;51(16):810-6. doi: 10.1007/BF01468076.

本文引用的文献

1
Cerebrospinal fluid in infants and children.婴幼儿的脑脊液
Med Clin North Am. 1950 Jan;34(1):107-18, illust.
2
[Paper-electrophoresis of cerebrospinal fluid].[脑脊液的纸电泳]
Klin Wochenschr. 1952 Apr 1;30(13-14):325-30. doi: 10.1007/BF01478498.
3
A critique of methods for determination of protein in cerebrospinal fluid.脑脊液中蛋白质测定方法的批判
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Electrophoretic studies on cerebrospinal fluid proteins.脑脊液蛋白质的电泳研究。
Scand J Clin Lab Invest. 1951;3(2):145-50. doi: 10.3109/00365515109060588.
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[Microelectrophoresis of cerebrospinal fluid in agar-gel].[脑脊液在琼脂凝胶中的微电泳]
Klin Wochenschr. 1958 Dec 1;36(23):1106-9. doi: 10.1007/BF01482176.
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A micro-electrophoretic method.一种微电泳方法。
Nature. 1958 Mar 22;181(4612):839-40. doi: 10.1038/181839a0.
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Study of cerebrospinal fluid proteins with paper electrophoresis. I. A review of literature.脑脊液蛋白质的纸电泳研究。I. 文献综述。
Med Bull (Ann Arbor). 1957 Jan;23(1):3-32.
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[Paper electrophoresis of cerebrospinal fluid].[脑脊液的纸电泳]
Arch Klin Exp Dermatol. 1955;201(5):446-77.
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A study of normal human cerebrospinal fluid by the immuno-electrophoretic mentod.用免疫电泳法对正常人脑脊液进行的一项研究。
Nature. 1955 Nov 19;176(4490):976. doi: 10.1038/176976a0.
10
The total spinal fluid protein concentration in patients over 65.65岁以上患者的脑脊液总蛋白浓度。
Geriatrics. 1955 Nov;10(11):533-5.