Vermes L M
Arq Neuropsiquiatr. 1983 Mar;41(1):9-24. doi: 10.1590/s0004-282x1983000100002.
The total protein content and protein fractions, obtained by electrophoresis on cellulose acetate strips, of CSF collected from the cisterna magna of 213 patients (with no neurological diseases) were determined in order to verify variations related to race, sex and age, as well as to establish the proteinogram normal limits. No differences between caucasians and coloured persons were observed with respect to CSF total protein and protein fractions. Children (5 months to 11 years old) do not present differences related to sex or age, on their proteinogram. Children's CSF total protein, relative values of pre-albumin, alpha 1--and beta-globulins, absolute values of albumin, alfa 2--, beta--, tau --and gamma-globulins, differ from those found in adults. Differences between males and females in the normal CSF proteinogram were found in adults. As a consequence of these findings, the CSF proteinogram normal limits for children, males and females were separately established. In adults, statistically significant positive correlation between age and the 7 protein fractions when expressed in mg/100 ml were observed, as well as between age and total protein. Comparison of the results obtained in this research with those found in some publications was carried out and is briefly discussed.
对213例（无神经疾病）患者从枕大池采集的脑脊液，通过在醋酸纤维素条上进行电泳，测定其总蛋白含量和蛋白组分，以验证与种族、性别和年龄相关的差异，并确定蛋白电泳图谱的正常范围。在脑脊液总蛋白和蛋白组分方面，未观察到白种人和有色人种之间存在差异。儿童（5个月至11岁）的蛋白电泳图谱在性别或年龄方面不存在差异。儿童脑脊液的总蛋白、前白蛋白、α1和β球蛋白的相对值、白蛋白、α2、β、τ和γ球蛋白的绝对值与成人不同。在正常脑脊液蛋白电泳图谱中，发现成年人存在男女差异。基于这些发现，分别确定了儿童、男性和女性的脑脊液蛋白电泳图谱正常范围。在成年人中，观察到年龄与以mg/100 ml表示的7种蛋白组分之间以及年龄与总蛋白之间存在统计学上显著的正相关。将本研究获得的结果与一些出版物中的结果进行了比较并进行了简要讨论。
