BROOME A W, GREENHALGH N
Br J Pharmacol Chemother. 1961 Dec;17(3):321-6. doi: 10.1111/j.1476-5381.1961.tb01119.x.
Critical studies using mice infected experimentally with nematodes (Nematospiroides dubius, Nippostrongylus muris and Heterakis spumosa) have shown methyridine to be an extremely effective anthelmintic when administered orally or subcutaneously. Comparisons of the two treatment regimes show subcutaneous administration to be the more efficient in terms of absolute dose, but neither treatment has a significant advantage in therapeutic safety margin. Methyridine has a more uniform anthelmintic action than either phenothiazine or bephenium against adult forms of the three test nematodes. In addition the drug possesses activity against all stages of certain immature nematode infections.
使用实验感染线虫（Dubius线虫、鼠类圆线虫和泡翼线虫）的小鼠进行的关键研究表明，美沙利啶经口服或皮下给药时是一种极其有效的驱虫药。两种给药方案的比较表明，就绝对剂量而言，皮下给药更有效，但在治疗安全范围方面，两种给药方式均无显著优势。与吩噻嗪或苄酚宁相比，美沙利啶对三种受试线虫成虫的驱虫作用更为均匀。此外，该药物对某些未成熟线虫感染的各个阶段均具有活性。
