文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zarrindast M R, Hajian-Heydari A, Hoseini-Nia T

Department of Pharmacology, Medical Faculty, University of Tehran, Iran.

Gen Pharmacol. 1992 May;23(3):427-30. doi: 10.1016/0306-3623(92)90106-t.

The possible involvement of subtypes of dopamine-receptors in apomorphine induced pecking was studied in pigeons. Different doses of apomorphine induced pecking in pigeons which was dose-dependent. 2. The response was decreased by SCH 23390 (D-1 antagonist) or high doses of sulpiride (D-2 antagonist) pretreatment, but increased by lower doses of sulpiride. 3. Combination of SCH 23390 with sulpiride completely antagonized the apomorphine effect. 4. Single dose administration of SKF 38393 (D-1 agonist) or bromocriptine (D-2 agonist) and combination of these drugs did not induce pecking, although either SK 23390 or bromocriptine increased the apomorphine-induced pecking which was decreased by SCH 23390 or sulpiride pretreatment. 5. It may be concluded that pecking, induced by apomorphine in pigeons, is elicited through activation of both D-1 and D-2 dopamine-receptors.

研究了多巴胺受体亚型在阿扑吗啡诱导的家鸽啄羽行为中的可能作用。不同剂量的阿扑吗啡可诱导家鸽啄羽，且呈剂量依赖性。2. 用SCH 23390（D-1拮抗剂）或高剂量舒必利（D-2拮抗剂）预处理可使反应减弱，但低剂量舒必利预处理则使反应增强。3. SCH 23390与舒必利联合使用可完全拮抗阿扑吗啡的作用。4. 单剂量给予SKF 38393（D-1激动剂）或溴隐亭（D-2激动剂）以及这两种药物联合使用均未诱导啄羽，尽管SK 23390或溴隐亭均可增强阿扑吗啡诱导的啄羽行为，而该行为可被SCH 23390或舒必利预处理减弱。5. 可以得出结论，阿扑吗啡诱导的家鸽啄羽行为是通过激活D-1和D-2多巴胺受体引发的。

Zarrindast M R, Hajian-Heydari A, Hoseini-Nia T

Department of Pharmacology, Medical Faculty, University of Tehran, Iran.

Gen Pharmacol. 1992 May;23(3):427-30. doi: 10.1016/0306-3623(92)90106-t.

The possible involvement of subtypes of dopamine-receptors in apomorphine induced pecking was studied in pigeons. Different doses of apomorphine induced pecking in pigeons which was dose-dependent. 2. The response was decreased by SCH 23390 (D-1 antagonist) or high doses of sulpiride (D-2 antagonist) pretreatment, but increased by lower doses of sulpiride. 3. Combination of SCH 23390 with sulpiride completely antagonized the apomorphine effect. 4. Single dose administration of SKF 38393 (D-1 agonist) or bromocriptine (D-2 agonist) and combination of these drugs did not induce pecking, although either SK 23390 or bromocriptine increased the apomorphine-induced pecking which was decreased by SCH 23390 or sulpiride pretreatment. 5. It may be concluded that pecking, induced by apomorphine in pigeons, is elicited through activation of both D-1 and D-2 dopamine-receptors.

研究了多巴胺受体亚型在阿扑吗啡诱导的家鸽啄羽行为中的可能作用。不同剂量的阿扑吗啡可诱导家鸽啄羽，且呈剂量依赖性。2. 用SCH 23390（D-1拮抗剂）或高剂量舒必利（D-2拮抗剂）预处理可使反应减弱，但低剂量舒必利预处理则使反应增强。3. SCH 23390与舒必利联合使用可完全拮抗阿扑吗啡的作用。4. 单剂量给予SKF 38393（D-1激动剂）或溴隐亭（D-2激动剂）以及这两种药物联合使用均未诱导啄羽，尽管SK 23390或溴隐亭均可增强阿扑吗啡诱导的啄羽行为，而该行为可被SCH 23390或舒必利预处理减弱。5. 可以得出结论，阿扑吗啡诱导的家鸽啄羽行为是通过激活D-1和D-2多巴胺受体引发的。