Burke W
J Med Genet. 1976 Dec;13(6):462-5. doi: 10.1136/jmg.13.6.462.
In a recent publication Brackenridge and Teltscher (1975) concluded that the age of onset of Huntington's disease was in part a function of the age of the transmitting parent at the time of birth of a subsequently affected child. Their analysis suggested that the younger the parent was at the time of birth of the subsequently affected child, the later in life symptoms of disease would appear in the child. The data of Brackenridge and Teltscher have been statistically reevaluated here, and this analysis fails to support their conclusion. Consequently it would be irresponsible to counsel persons at risk for Huntington's disease to plan families early in life.
在最近的一篇出版物中，布莱克里奇和特尔切尔（1975年）得出结论，亨廷顿氏病的发病年龄部分取决于受影响子女出生时传递基因的父母的年龄。他们的分析表明，在受影响子女出生时父母年龄越小，子女出现疾病症状的时间就越晚。在此对布莱克里奇和特尔切尔的数据进行了统计重新评估，而此次分析未能支持他们的结论。因此，向有患亨廷顿氏病风险的人建议在年轻时就规划家庭是不负责任的。
