McCance-Katz E F, Marek K L, Price L H
Connecticut Mental Health Center, Department of Psychiatry, New Haven.
Neurology. 1992 Sep;42(9):1813-4. doi: 10.1212/wnl.42.9.1813.
A 55-year-old man presented with a 5-year history of Parkinson's disease and a 6-month history of major depression. The patient's depressive symptoms responded to treatment with fluvoxamine, a selective and potent serotonin reuptake inhibitor. Tryptophan depletion testing, which acutely lowers central serotonin levels, caused a brief exacerbation of the depressive illness, which resolved upon tryptophan repletion. Serotonergic dysfunction may be an etiologic factor in depression that occurs in Parkinson's disease.
一名55岁男性，有5年帕金森病病史及6个月重度抑郁病史。患者的抑郁症状对氟伏沙明（一种选择性强效血清素再摄取抑制剂）治疗有反应。色氨酸耗竭试验可急性降低中枢血清素水平，该试验导致抑郁病情短暂加重，补充色氨酸后病情缓解。血清素功能障碍可能是帕金森病伴发抑郁的一个病因。
