Aleĭnik S I, Kodentsiva V M, Mitin I E, Sokol'nikov A A, Vrzhesinskaia O A, Isaeva V A, Terekhina T A, Stroganova A S, Erzhen K, Tsibul'skaia O A
Vopr Pitan. 1992 May-Jun(3):14-9.
Providing of children aged 3-5 years with vitamins C, B1, B2, B6 and PP was studied before and after intake (during 3 months) of multivitamin "Pikovit" (KRKA, Yugoslavia) by the excretion with urine of ascorbic acid, thiamine, riboflavin, 4-pyridoxic acid and N-methylnicotinamide. Before "Pikovit" intake the mean level of thiamine excretion was close to the lower border of the normal level, while ascorbic acid and N-methylnicotinamide levels were lower than the normal in 73 and 69% of the children studied, respectively. "Pikovit" induced an increase in the mean values of excretion of all vitamins studied except for ascorbic acid. The multivitamin prevented the impairment of children providing with vitamins C and B6, and improved their provision with vitamins B1, B2 and PP. However, the doses of vitamins used proved to be insufficient for complete normalization of the vitamin status in children, therefore it is necessary to use "Pikovit" in higher doses as it is recommended by the firm-manufacturer.
通过抗坏血酸、硫胺素、核黄素、4-吡哆酸和N-甲基烟酰胺的尿排泄情况，研究了3至5岁儿童在摄入（为期3个月）复合维生素“匹可维生素”（南斯拉夫KRKA公司生产）前后维生素C、B1、B2、B6和PP的情况。在摄入“匹可维生素”之前，硫胺素排泄的平均水平接近正常水平的下限，而在所研究儿童中，分别有73%和69%的儿童抗坏血酸和N-甲基烟酰胺水平低于正常水平。“匹可维生素”使除抗坏血酸外所有所研究维生素的排泄平均值增加。该复合维生素预防了儿童维生素C和B6供应不足的情况，并改善了他们维生素B1、B2和PP的供应情况。然而，事实证明所用维生素剂量不足以使儿童的维生素状态完全正常化，因此有必要按照生产厂家的建议以更高剂量使用“匹可维生素”。
