Başaran N, Cenani A, Sayli B S, Ozkinay C, Artan S, Seven H, Başaran A, Dinçer S
Department of Medical Genetics, Anadolu University Medical Faculty, Eskişehir, Turkey.
Clin Genet. 1992 Jul;42(1):13-5. doi: 10.1111/j.1399-0004.1992.tb03127.x.
In order to reveal if there is an effect on the genesis of meiotic- or early zygotic non-disjunctions, data related to 1598 Down syndrome patients from 1578 families studied in five different genetic centers in Turkey are reported. Parental consanguinity and the inbreeding coefficient were found to be lower among patients of 21-trisomics than in parents without Down offspring. It was concluded that available information does not support the presence of a "non-disjunction gene" in man.
为了揭示是否对减数分裂或早期合子不分离的发生有影响，报告了在土耳其五个不同遗传中心研究的1578个家庭中1598名唐氏综合征患者的相关数据。发现21 - 三体患者的父母近亲结婚率和近亲繁殖系数低于没有唐氏后代的父母。得出的结论是，现有信息不支持人类中存在“不分离基因”。
