Barrett T W
Biosystems. 1976 Dec;8(3):103-9. doi: 10.1016/0303-2647(76)90013-7.
The dynamic properties of hyaluronate solutions are discussed with relevance to some problems in sensory physiology (mechanoelectrical transduction), renal physiology, interstitial fluid regulation, and especially to the causes of open-angle glaucoma. With respect to the last problem: as recent biochemical evidence indicates that the hyaloid membrane does not exist, it now seems worthwhile to consider the increase in intraocular pressure present in the eye with glaucoma to be due--at least in the open-angle case--to a change in the specific gravity and hydrophilic nature of the hyaluronic acid in the vitreous body in particular, as well as in the trabecular meshwork. Densimetric experimental evidence indicates that the hyaluronate system could, indeed, produce the pressure changes seen in glaucoma, if intraocular pH changed but slightly. A hypothesis concerning the effect of acetazol amide on intraocular pressure is also presented.
本文讨论了透明质酸盐溶液的动力学性质，及其与感觉生理学（机械电转导）、肾脏生理学、组织液调节等方面的一些问题的相关性，尤其涉及开角型青光眼的病因。关于最后一个问题：由于最近的生化证据表明玻璃体膜并不存在，现在看来有必要考虑青光眼患者眼内压升高——至少在开角型病例中——特别是由于玻璃体以及小梁网中透明质酸的比重和亲水性发生变化所致。密度测定实验证据表明，如果眼内pH值稍有变化，透明质酸盐系统确实可能产生青光眼所见的压力变化。本文还提出了一个关于乙酰唑胺对眼内压影响的假说。
