Pinto G M, Lamarão P, Vale T
Department of Dermatology, Curry Cabral Hospital, Lisboa, Portugal.
J Am Acad Dermatol. 1992 Aug;27(2 Pt 2):281-4. doi: 10.1016/0190-9622(92)70180-n.
A 78-year-old woman developed intertriginous vegetating plaques, mouth ulcers, and a cerebriform tongue after 11 months of captopril therapy. Findings of clinical, histologic, and immunofluorescence testing were consistent with a diagnosis of pemphigus vegetans. In addition, Charcot-Leyden crystals were observed within some of the intraepidermal, eosinophilic abscess cavities, which were bordered by granular cells undergoing keratinization. The skin lesions cleared rapidly after discontinuation of captopril. To the best of our knowledge, this report describes the first case of pemphigus vegetans induced by captopril.
一名78岁女性在接受卡托普利治疗11个月后出现擦烂性增殖性斑块、口腔溃疡和脑回状舌。临床、组织学和免疫荧光检查结果符合增殖性天疱疮的诊断。此外，在一些表皮内嗜酸性脓肿腔内观察到夏科-莱登结晶，这些脓肿腔由正在角化的颗粒细胞构成边界。停用卡托普利后，皮肤病变迅速消退。据我们所知，本报告描述了首例由卡托普利诱发的增殖性天疱疮病例。
