Blanken R, Doeglas H M, de Jong M C, Kardaun S H, van Leeuwen M
Department of Dermatology, University Hospital Groningen, The Netherlands.
Acta Derm Venereol. 1988;68(5):456-7.
A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that both these chemically related drugs might have been responsible for the pemphigus-like eruption in this patient.
