前列腺素和收缩压，而非血管紧张素II，独立影响人体中的心房利钠肽水平。

Prostaglandins and systolic blood pressure, but not angiotensin II, independently affect atrial natriuretic peptide levels in man.

Klemm S A, Gordon R D, Tunny T J, Finn W L, Hornych A

Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1992 May;19(5):323-6. doi: 10.1111/j.1440-1681.1992.tb00463.x.

Abstract

Two hours after a single dose of indomethacin (INDO), plasma renin activity (PRA) and atrial natriuretic peptide (ANP) levels decreased, which is consistent with an effect of lowering prostaglandins (PG). 2. After 48 h of INDO, PRA remained low but ANP had increased, which is consistent with the known effect of prostaglandin inhibitors to cause sodium retention, with a resulting volume expansion. 3. Infusions of angiotension II (AII), which raises diastolic blood pressure (BP) 20 mmHg or more, consistently raised ANP levels. The ANP response to AII infusion was reduced 48 h after INDO, which is consistent with an important role for PG in AII-stimulated ANP release. 4. After PG were blocked with INDO, the stimulating effect of AII on ANP at doses that increased diastolic BP less than 20 mmHg was insignificant, whereas before INDO it was significant. 5. In dose-response studies, INDO increased the systolic BP response but decreased the ANP response to AII, which is consistent with a direct effect of PG on ANP that is independent of systolic BP. 6. Prostaglandins and BP are important in the ANP response to AII infusion in normal subjects, but AII itself appears to have little direct effect on ANP.

摘要

单次给予吲哚美辛（INDO）两小时后，血浆肾素活性（PRA）和心房利钠肽（ANP）水平下降，这与降低前列腺素（PG）的作用一致。2. INDO用药48小时后，PRA仍维持在低水平，但ANP升高，这与前列腺素抑制剂导致钠潴留并进而引起血容量扩张的已知作用相符。3. 输注血管紧张素II（AII）使舒张压（BP）升高20 mmHg或更多，持续升高ANP水平。INDO用药48小时后，ANP对AII输注的反应降低，这与PG在AII刺激的ANP释放中起重要作用相符。4. 用INDO阻断PG后，AII在使舒张压升高小于20 mmHg剂量时对ANP的刺激作用不显著，而在INDO用药前则显著。5. 在剂量反应研究中，INDO增加了收缩压反应，但降低了ANP对AII的反应，这与PG对ANP的直接作用一致，且该作用独立于收缩压。6. 前列腺素和血压在正常受试者ANP对AII输注的反应中起重要作用，但AII本身似乎对ANP几乎没有直接作用。