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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Finn W L, Tunny T J, Klemm S A, Ryan S J, Gordon R D

University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1993 May;20(5):392-4. doi: 10.1111/j.1440-1681.1993.tb01714.x.

Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) but not with age. 3. This is consistent with the response of ANP to AII being mediated partly by the rise in blood pressure, independent of ageing. 4. As expected in a selected normotensive population, there was no correlation between basal blood pressure and age, but pressor slope was positively correlated with age. 5. Thus, dose-response relationships may be an index of age-induced alterations in pressure regulatory mechanisms.

对正常受试者输注递增剂量的血管紧张素II（AII）会依次增加血压、醛固酮和心房利钠肽（ANP）水平。2. ANP对AII反应的斜率与基础ANP以及血压对AII反应的斜率（升压斜率）呈正相关，但与年龄无关。3. 这与ANP对AII的反应部分由血压升高介导且与衰老无关是一致的。4. 正如在选定的正常血压人群中所预期的那样，基础血压与年龄之间没有相关性，但升压斜率与年龄呈正相关。5. 因此，剂量反应关系可能是年龄引起的压力调节机制改变的一个指标。

Finn W L, Tunny T J, Klemm S A, Ryan S J, Gordon R D

University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1993 May;20(5):392-4. doi: 10.1111/j.1440-1681.1993.tb01714.x.

Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) but not with age. 3. This is consistent with the response of ANP to AII being mediated partly by the rise in blood pressure, independent of ageing. 4. As expected in a selected normotensive population, there was no correlation between basal blood pressure and age, but pressor slope was positively correlated with age. 5. Thus, dose-response relationships may be an index of age-induced alterations in pressure regulatory mechanisms.

对正常受试者输注递增剂量的血管紧张素II（AII）会依次增加血压、醛固酮和心房利钠肽（ANP）水平。2. ANP对AII反应的斜率与基础ANP以及血压对AII反应的斜率（升压斜率）呈正相关，但与年龄无关。3. 这与ANP对AII的反应部分由血压升高介导且与衰老无关是一致的。4. 正如在选定的正常血压人群中所预期的那样，基础血压与年龄之间没有相关性，但升压斜率与年龄呈正相关。5. 因此，剂量反应关系可能是年龄引起的压力调节机制改变的一个指标。