Blatt J, Proujansky R, Horn M, Phebus C, Longworth D, Penchansky L
Department of Pediatrics, Children's Hospital, Pittsburgh, Pennsylvania 15213-3417.
Pediatr Hematol Oncol. 1992 Apr-Jun;9(2):151-5. doi: 10.3109/08880019209018330.
Idiopathic hypereosinophilic syndrome (IHES) is a heterogeneous group of disorders characterized by multisystem dysfunction and persistent, extreme eosinophilia of unknown cause. We describe a 9-1/2-year-old boy whose course included several unusual clinical features and terminated 2 years after diagnosis in acute lymphoblastic leukemia (ALL). Serial studies suggest that leukemia was not present earlier in his course. We speculate that this child may have had an evolving lymphoproliferative syndrome with a terminal blast crisis to which the eosinophilia was a nonmalignant leukemoid reaction.
特发性嗜酸性粒细胞增多综合征（IHES）是一组异质性疾病，其特征为多系统功能障碍以及原因不明的持续性、极度嗜酸性粒细胞增多。我们描述了一名9岁半的男孩，其病程包含一些不寻常的临床特征，并在诊断为急性淋巴细胞白血病（ALL）后2年死亡。系列研究表明白血病在其病程早期并不存在。我们推测这个孩子可能患有逐渐发展的淋巴增殖性综合征，最终发生原始细胞危象，而嗜酸性粒细胞增多是一种非恶性类白血病反应。
