哇巴因和依他尼酸对大鼠和豚鼠内耳ATP酶活性的影响。

The effect of ouabain and ethacrynic acid on ATPase activities in the inner ear of the rat and guinea pig.

作者信息

Kuijpers W, Wilberts D P

出版信息

ORL J Otorhinolaryngol Relat Spec. 1976;38(6):321-7. doi: 10.1159/000275291.

Abstract

The effect of ethacrynic acid on ATPase activities in the stria vascularis of rat and guinea pig inner ear was studied. Both Na-K- and Mg-activated ATPase activities were inhibited non-selectively only at very high concentrations of ethacrynic acid, in contrast to the selective inhibition of Na-K-ATPase activity by ouabain. It is suggested that the deleterious effect of ethacrynic acid on the inner ear may be due to its effect on the general metabolism of the cell rather than on the ionic transport system.

摘要

研究了依他尼酸对大鼠和豚鼠内耳血管纹中ATP酶活性的影响。与哇巴因对钠钾ATP酶活性的选择性抑制相反，仅在非常高浓度的依他尼酸时，钠钾ATP酶和镁激活的ATP酶活性才会受到非选择性抑制。提示依他尼酸对内耳的有害作用可能是由于其对细胞一般代谢的影响，而非对离子转运系统的影响。