依他尼酸对大鼠肥大细胞膜上钙和镁激活的三磷酸腺苷酶的抑制作用
Ethacrynic acid inhibitable Ca2+ and Mg2+-activated membrane adenosine triphosphatase in rat mast cells.
作者信息
Magro A M
出版信息
Clin Exp Immunol. 1977 Oct;30(1):160-7.
Abstract
A crude plasma membrane fraction from the homogenate of purified rat mast cells demonstrates a high degree of Ca2+-dependent and Mg2+-dependent adenosine triphosphatase (ATPase) activity. The microsomal and mitochondrial fractions show negligible amounts of the Ca2+ and Mg2+-activated ATPases. The broad ATPase inhibitor, ethacrynic acid, effectively blocks the mast cell ATPase activity while ouabain demonstrates little inhibitory effect. Correspondingly, ethacrynic acid inhibits histamine release from antigen-challenged mast cells while ouabain does not. Both ATPase inhibition and histamine release inhibition by ethacrynic acid require the presence of the olefinic bond in the ethacrynic acid molecule.
摘要
从纯化的大鼠肥大细胞匀浆中提取的粗制质膜组分显示出高度的钙依赖性和镁依赖性三磷酸腺苷酶（ATP酶）活性。微粒体和线粒体组分中钙和镁激活的ATP酶含量可忽略不计。广泛的ATP酶抑制剂依他尼酸可有效阻断肥大细胞ATP酶活性，而哇巴因几乎没有抑制作用。相应地，依他尼酸可抑制抗原刺激的肥大细胞释放组胺，而哇巴因则不能。依他尼酸对ATP酶的抑制作用和对组胺释放的抑制作用都需要依他尼酸分子中烯键的存在。
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