注射大鼠和兔肝脏核糖体的兔的自身免疫反应。
Autoimmune response in rabbits injected with rat and rabbit liver ribosomes.
作者信息
DODD M C, BIGLEY N J, GEYER V B, McCOY F W, WILSON H E
出版信息
Science. 1962 Aug 31;137(3531):688-9. doi: 10.1126/science.137.3531.688.
PMID:13886836
Abstract
Autoimmune hemolytic anemia and leukopenia, circulating autoantibodies for erythrocytes, leukocytes, and ribosomes; pathological changes in liver, spleen, heart, brain, and kidneys were produced in rabbits injected with rat or rabbit liver ribosomes. The hematologic and pathologic changes were reproduced by injection of anti-ribosomal serum into normal rabbits. The autoantibody specificity was related primarily to nucleotides and nucleosides.
摘要
自身免疫性溶血性贫血和白细胞减少症，存在针对红细胞、白细胞和核糖体的循环自身抗体；给注射大鼠或兔肝脏核糖体的兔子造成肝脏、脾脏、心脏、脑和肾脏的病理变化。通过向正常兔子注射抗核糖体血清再现血液学和病理学变化。自身抗体特异性主要与核苷酸和核苷相关。
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