实验性红细胞自身免疫。II. 血液中存在的自身抗体特异性抑制细胞。
Experimental erythrocyte autoimmunity. II. Autoantibody-specific suppressor cells present in blood.
作者信息
Gare N F, Cox K O
出版信息
Int Arch Allergy Appl Immunol. 1980;62(2):227-30.
PMID:6445340
Abstract
Mice injected with rat RBC produce RBC autoantibodies and spleen cells that delay autoantibody production. In this report it is shown that transfer of 5 X 10(6) blood leukocytes from mice producing autoantibodies to syngeneic recipients before the injections of rat RBC were started, significantly delayed autoantibody production. These circulating suppressor cells were effective if transferred up to 3 weeks before the first injection of rat RBC and were destroyed by 2,000 rad of irradiation before transfer.
摘要
注射大鼠红细胞的小鼠会产生红细胞自身抗体以及延迟自身抗体产生的脾细胞。在本报告中表明，在开始注射大鼠红细胞之前，将来自产生自身抗体小鼠的5×10⁶个血液白细胞转移至同基因受体，可显著延迟自身抗体的产生。这些循环抑制细胞在首次注射大鼠红细胞前3周内转移均有效，且在转移前经2000拉德辐射会被破坏。
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Experimental erythrocyte autoimmunity. II. Autoantibody-specific suppressor cells present in blood.实验性红细胞自身免疫。II. 血液中存在的自身抗体特异性抑制细胞。
Int Arch Allergy Appl Immunol. 1980;62(2):227-30.
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