Dranga A, Marinov R, Mihai M, Teodorescu C
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1976 Oct-Dec;21(4):219-25.
Immunoepidemiological investigations were carried out in a family in which a child with congenital toxoplasmosis was born in 1972. The following were determined: total fluorescent antibodies and their G and M fractions and G and M serum immunoglobulins. The results showed: --the existence of a familial focus if infection with T. gondii, the risk of infection in the course of pregnancy and its consequences on the product of conception; --the normal evolution of the following pregnancy in the presence of anti-T. gondii fluorescent antibodies and the birth of a normal child; --value of the indirect immunofluorescence test for the diagnosis of congenital toxoplasmosis and of the longitudinal immunologic investigation; --determination of the antibody M fraction and serum immunoglobulins did not prove as useful as expected; --persistance of fluorescent antibodies in significant titers over a long period in the absence of a clinical symptomatology or with clinical manifestations of another etiology might lead to a false diagnosis of toxoplasmosis -- hence the necessity of a test for differentiating the carrier of specific antibodies from the toxoplasmosis patient.
1972年，在一个有先天性弓形虫病患儿出生的家庭中开展了免疫流行病学调查。测定了以下指标：总荧光抗体及其G和M组分以及血清免疫球蛋白G和M。结果显示：——存在弓形虫感染的家族聚集性、孕期感染风险及其对妊娠产物的影响；——在存在抗弓形虫荧光抗体的情况下，后续妊娠的正常进展以及一个正常孩子的出生；——间接免疫荧光试验对先天性弓形虫病诊断及纵向免疫学调查的价值；——抗体M组分和血清免疫球蛋白的测定结果未证明如预期般有用；——在无临床症状或有其他病因临床表现的情况下，荧光抗体长时间持续存在高滴度可能导致弓形虫病的误诊——因此有必要进行一项检测以区分特异性抗体携带者和弓形虫病患者。
