Mihai M, Marinov R, Baciu G, Rener L, Vînătoru E, Blum L, Chirculescu O, Tîrziman I, Pricop M
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1978 Jul-Sep;23(3):147-52.
The indirect immunofluorescence test was carried out in 500 pregnant women in urban and rural areas, with a view to following conversion to seronegative values. The evolution of the immune background in infection with T. gondii was followed up by comparative analysis of the seroepidemiological data obtained in 1976 and 1977. It was found that:--Variations in the intensity of endogenous and exogenous factors bring about changes in the frequency and intensity of the immune response in toxoplasmosis.--Postnatal evolution of the child can be correlated with the age of pregnancy when seroconversion accurred and with the intensity of the latter.--The predominance of seroconversion in the 6th and 7th month of pregnancy and negativation of some of the responses during pregnancy suggest the need of an additional serological control during these months.--The effect of optimal conditions during springtime resulted in seasonal appearance of seroconversions, offering an additional orientation.--In the neonates of seropositive mothers no cases of manifest disease were observed; the presence of infection has to be subsequently confirmed or invalidated.
对500名城乡孕妇进行了间接免疫荧光试验，旨在追踪血清转化为阴性值的情况。通过对1976年和1977年获得的血清流行病学数据进行比较分析，对弓形虫感染的免疫背景演变进行了随访。结果发现：——内源性和外源性因素强度的变化导致弓形虫病免疫反应的频率和强度发生改变。——儿童出生后的发育与血清转化发生时的妊娠年龄以及血清转化强度相关。——妊娠第6和第7个月血清转化占优势以及妊娠期间某些反应转阴，表明在这些月份需要额外进行血清学检查。——春季最佳条件的影响导致血清转化出现季节性变化，提供了额外的指导方向。——在血清阳性母亲的新生儿中未观察到明显疾病病例；感染的存在随后必须得到证实或排除。
