Munro C S, Cox N H
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Br J Dermatol. 1992 Aug;127(2):168-71. doi: 10.1111/j.1365-2133.1992.tb08051.x.
Many epidermal naevi with the histology of Darier's disease have been reported. In the absence of associated features of Darier's disease, they cannot be assumed to have a common pathogenesis with it, and it has been suggested that they are better classified as acantholytic dyskeratotic epidermal naevi rather than naevoid Darier's disease. We describe a patient with such a naevus who had typical nail and palmar changes of Darier's disease on the same side of the body. We suggest that in at least some cases the naevus has the same genetic defect(s) as generalized Darier's disease, and discuss the possibility that a patient with such a naevus could occasionally transmit Darier's disease to an offspring.
已有许多具有达里埃病组织学特征的表皮痣的报道。在缺乏达里埃病相关特征的情况下，不能认为它们与达里埃病有共同的发病机制，有人提出将它们更好地归类为棘层松解性角化不良性表皮痣，而非痣样达里埃病。我们描述了一名患有此类痣的患者，其身体同一侧出现了典型的达里埃病的甲和掌部改变。我们认为至少在某些情况下，该痣与泛发性达里埃病具有相同的基因缺陷，并讨论了患有此类痣的患者偶尔可能将达里埃病遗传给后代的可能性。
