HODGE R L, WHELAN R F
Br J Pharmacol Chemother. 1962 Apr;18(2):331-6. doi: 10.1111/j.1476-5381.1962.tb01413.x.
Intra-arterial infusion of hexamethonium into the brachial artery had no potentiating effect on the constrictor response of the vessels of the forearm or hand to noradrenaline given by the same route. The response of the hand vessels to intravenous infusion of noradrenaline was enhanced after intra-arterial hexamethonium, but this was attributed to entry of the blocking agent into the general circulation resulting in blockade of baroreceptor reflexes since the potentiation was seen to an equal degree on both sides. It is concluded that if increased sensitivity to noradrenaline plays a part in the phenomenon of tolerance to hexamethonium this must be a slowly developing effect.
将六甲铵经肱动脉进行动脉内输注，对前臂或手部血管对经相同途径给予的去甲肾上腺素的收缩反应没有增强作用。动脉内注射六甲铵后，手部血管对静脉输注去甲肾上腺素的反应增强，但这归因于阻断剂进入体循环导致压力感受器反射被阻断，因为两侧的增强程度相同。得出的结论是，如果对去甲肾上腺素敏感性增加在六甲铵耐受性现象中起作用，那么这一定是一种缓慢发展的效应。
