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产褥期起病和非产褥期起病的分裂情感性障碍。

Schizoaffective disorders with and without onset in the puerperium.

作者信息

Rohde A, Marneros A

机构信息

University of Bonn, Psychiatric Department, Federal Republic of Germany.

出版信息

Eur Arch Psychiatry Clin Neurosci. 1992;242(1):27-33. doi: 10.1007/BF02190339.

Abstract

The premorbid and sociodemographic features, long-term course and long-term outcome (on average 23.8 resp. 26.8 years after onset of illness) were compared in 30 female schizoaffective patients with onset of their illness during the puerperium and 60 female schizoaffective patients with onset at other times. The majority of premorbid and sociodemographic variables as well as course parameters were similar in the two groups. Most of the few differences (in age at first manifestation, marital state at onset, presence of stable heterosexual relationship before onset, acuteness of onset, presence of life events) are closely connected with the inclusion and exclusion criteria applied for the puerperal disorders (exclusion of patients with preexisting illness or psychiatric symptoms during pregnancy, inclusion only if onset was within 6 weeks of parturition). The puerperal schizoaffective disorders began more frequently with a schizomanic episode and less frequently with a schizodepressive episode than did the non-puerperal schizoaffective disorders, a finding which perhaps reflected the "pathoplastic" role of the puerperium on psychotic disorders. Several significant differences were found regarding the long-term outcome (frequency of persistent alterations, level of global functioning and disability, non-achievement of the expected social development, loss of autarky), confirming earlier findings that puerperal disorders generally have a better outcome than other psychotic disorders.

摘要

对30例产后发病的女性分裂情感性障碍患者和60例其他时期发病的女性分裂情感性障碍患者的病前和社会人口学特征、病程及长期预后(平均发病后分别为23.8年和26.8年)进行了比较。两组的大多数病前和社会人口学变量以及病程参数相似。少数差异(首次发病年龄、发病时婚姻状况、发病前是否存在稳定异性恋关系、起病急缓、是否存在生活事件)大多与产后疾病的纳入和排除标准密切相关(排除孕期已有疾病或精神症状的患者,仅在分娩后6周内发病者纳入)。与非产后分裂情感性障碍相比,产后分裂情感性障碍更常始于分裂躁狂发作,较少始于分裂抑郁发作,这一发现可能反映了产褥期对精神障碍的“致病塑造”作用。在长期预后方面发现了几个显著差异(持续性改变的频率、整体功能和残疾水平、未实现预期的社会发展、失去自理能力),证实了早期的研究结果,即产后疾病的预后通常比其他精神障碍更好。

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