Adams J B, Vrahimis R, Phillips N
School of Biochemistry, University of New South Wales, Sydney, Australia.
Breast Cancer Res Treat. 1992;22(2):157-61. doi: 10.1007/BF01833346.
The importance of the steroid hormone microenvironment within cells is now recognised in studies on endocrine-related neoplasms such as breast cancer. This focuses attention on enzymes which control the intracellular levels of estradiol-17 beta (E2). One such enzyme, estrogen sulfotransferase, which converts E2 to inactive E2-3 sulfate, has now been shown to be regulated by estrogen in MCF-7 human mammary cancer cells. Hydroxysteroid sulfotransferase, which sulfurylates the adrenal-derived estrogen 5-androstene-3 beta,17 beta-diol, is also under estrogen control. Evidence is provided which shows that one function of these enzymes may involve elimination of estrogen from the cell following processing of the ligand-charged estrogen receptor (ER).
目前，在乳腺癌等内分泌相关肿瘤的研究中，人们已经认识到细胞内类固醇激素微环境的重要性。这使得人们将注意力集中在控制雌二醇 - 17β（E2）细胞内水平的酶上。其中一种酶，即雌激素磺基转移酶，它将E2转化为无活性的E2 - 3硫酸盐，现已证明在MCF - 7人乳腺癌细胞中受雌激素调节。羟基类固醇磺基转移酶可使肾上腺来源的雌激素5 - 雄烯 - 3β，17β - 二醇硫酸化，它也受雌激素控制。有证据表明，这些酶的一个功能可能涉及在处理带配体的雌激素受体（ER）后将雌激素从细胞中清除。
