Pewnim T, Adams J B, Ho K P
Cancer Res. 1980 Apr;40(4):1360-2.
It was previously demonstrated that a correlation existed between estrogen receptor (ER) status and levels of estrogen sulfotransferase in human mammary cancer, high levels being associated with ER-positive and low levels with ER-negative tumors. We have now examined these same parameters, along with progesterone receptor (PGR) status, in 44 primary human mammary tumors. Tumors which were both ER-positive and PGR-positive (n = 21), showed significantly higher levels of estrogen sulfotransferase compared to ER-positive PGR-negative (n = 12) and ER-negative PGR-negative (n = 11) tumors. These values (pmol estradiol sulfate per mg protein per 2 hr) were 72 +/- 12 (S.E.), 25 +/- 5, and 11 +/- 4 (p less than 0.01 and less than 0.005, respectively). There was no significant difference between ER-positive PGR-negative and ER-negative PGR-negative tumors. The possible involvement of PGR in the regulation of estrogen sulfotransferase is discussed.
先前已证明，在人类乳腺癌中，雌激素受体（ER）状态与雌激素磺基转移酶水平之间存在相关性，高水平与ER阳性肿瘤相关，低水平与ER阴性肿瘤相关。我们现在在44例原发性人类乳腺肿瘤中检测了这些相同参数以及孕激素受体（PGR）状态。ER阳性且PGR阳性的肿瘤（n = 21）与ER阳性PGR阴性（n = 12）和ER阴性PGR阴性（n = 11）的肿瘤相比，雌激素磺基转移酶水平显著更高。这些值（每毫克蛋白质每2小时的硫酸雌二醇皮摩尔数）分别为72±12（标准误）、25±5和11±4（p分别小于0.01和小于0.005）。ER阳性PGR阴性和ER阴性PGR阴性肿瘤之间无显著差异。文中讨论了PGR在雌激素磺基转移酶调节中的可能作用。
