Uyama O, Shimizu S, Nakanishi T, Nakahama H, Takiguchi A, Hayashi Y, Yamamoto S, Sugita M
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Intern Med. 1992 Jun;31(6):735-9. doi: 10.2169/internalmedicine.31.735.
Thromboxane A2 (TXA2) biosynthesis was studied in healthy subjects, patients with chronic cerebral infarction, patients under chronic aspirin treatment and patients with atrial fibrillation. Urinary 11-dehydro-TXB2, as a major metabolite of TXA2, was measured by radioimmunoassay. The extent of carotid atherosclerosis was determined by B-mode ultrasonography. The mean +/- SD urinary excretion in patients with cerebral infarction and distinct carotid-atherosclerotic lesions (1,725 +/- 239 ng/g creatinine, n = 6) was significantly higher (p less than 0.01) than in healthy subjects (911 +/- 239 ng/g creatinine, n = 44) and patients with cerebral infarction who had no distinct carotid lesion (1,050 +/- 191 ng/g creatinine, n = 6). The urinary excretion of healthy subjects was higher (p less than 0.01) in smokers (1,063 +/- 244 ng/g creatinine, n = 17) than in non-smokers (815 +/- 183 ng/g creatinine, n = 27). Aspirin largely suppressed 11-dehydro-TXB2 excretion (266 +/- 114 ng/g creatinine, n = 7). Three of 5 patients with atrial fibrillation showed very high values. Our results indicated that platelet activation occurs in the atherosclerotic lesions, and that urinary 11-dehydro-TXB2 is the appropriate analytic target for detecting platelet activation.
在健康受试者、慢性脑梗死患者、长期接受阿司匹林治疗的患者以及心房颤动患者中研究了血栓素A2（TXA2）的生物合成。通过放射免疫分析法测定作为TXA2主要代谢产物的尿11-脱氢-TXB2。通过B型超声检查确定颈动脉粥样硬化的程度。有脑梗死且有明显颈动脉粥样硬化病变的患者（1,725±239 ng/g肌酐，n = 6）的尿排泄均值±标准差显著高于健康受试者（911±239 ng/g肌酐，n = 44）和无明显颈动脉病变的脑梗死患者（1,050±191 ng/g肌酐，n = 6）（p<0.01）。吸烟者（1,063±244 ng/g肌酐，n = 17）的健康受试者尿排泄高于非吸烟者（815±183 ng/g肌酐，n = 27）（p<0.01）。阿司匹林在很大程度上抑制了11-脱氢-TXB2的排泄（266±114 ng/g肌酐，n = 7）。5例心房颤动患者中有3例显示出非常高的值。我们的结果表明血小板激活发生在动脉粥样硬化病变中，并且尿11-脱氢-TXB2是检测血小板激活的合适分析靶点。
