• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

吸烟及戒烟对尿11-脱氢血栓烷B水平的影响

Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane B.

作者信息

van der Plas Angela, Pouly Sandrine, de La Bourdonnaye Guillaume, Ng Wee Teck, Baker Gizelle, Lüdicke Frank

机构信息

Product Assessment and Scientific Substantiation, Philip Morris International Research & Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland.

出版信息

Toxicol Rep. 2018 Apr 19;5:561-567. doi: 10.1016/j.toxrep.2018.04.005. eCollection 2018.

DOI:10.1016/j.toxrep.2018.04.005
PMID:29854626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5977536/
Abstract

BACKGROUND

Thromboxane is a key clinical risk endpoint of smoking-induced inflammation which has been associated in the pathogenesis of cardiovascular disease. The goal of this review is to quantify the effect of smoking and smoking cessation on one of its urinary metabolites, 11-dehydrothromboxane.

METHODS

PubMed and SCOPUS were searched to identify publications which report urinary 11-dehydrothromboxane levels in smokers and non-smokers, as well as articles reporting the effect of smoking cessation on urinary 11-dehydrothromboxane excretion.

RESULTS

We found ten studies assessing urinary 11-dehydrothroboxane levels in smokers and non-smokers. Four papers reported the amount of urinary 11-dehydrothromboxane excreted in 24 h while six reported the amount excreted adjusted for creatinine. The meta-analyses comparing the excretion of urinary 11-dehydrothromboxane in current smokers to non-smokers report increased levels in current smokers (mean difference = 0.31 μg/24-h [95%CI: 0.27-0.34] and 166.45 pg/mg creatinine [95%CI: 120.51-212.40]). There were not enough publications to perform meta-analyses on the effects of smoking cessation on urinary 11-dehydrothromboxane excretion.

CONCLUSIONS

Urinary 11-dehydrothromboxane levels are increased in cigarette smokers, however, more data are needed to elucidate the effects of smoking cessation on urinary 11-dehydrothromboxane excretion.

摘要

背景

血栓素是吸烟诱导炎症的关键临床风险终点，与心血管疾病的发病机制相关。本综述的目的是量化吸烟和戒烟对其尿液代谢物之一11 - 脱氢血栓素的影响。

方法

检索PubMed和SCOPUS以识别报告吸烟者和非吸烟者尿液中11 - 脱氢血栓素水平的出版物，以及报告戒烟对尿液中11 - 脱氢血栓素排泄影响的文章。

结果

我们发现了十项评估吸烟者和非吸烟者尿液中11 - 脱氢血栓素水平的研究。四篇论文报告了24小时内尿液中11 - 脱氢血栓素的排泄量，六篇报告了经肌酐校正后的排泄量。对当前吸烟者与非吸烟者尿液中11 - 脱氢血栓素排泄量进行的荟萃分析报告显示，当前吸烟者的水平升高（平均差异= 0.31μg/24小时[95%置信区间：0.27 - 0.34]和166.45pg/mg肌酐[95%置信区间：120.51 - 212.40]）。没有足够的出版物对戒烟对尿液中11 - 脱氢血栓素排泄的影响进行荟萃分析。

结论

吸烟者尿液中11 - 脱氢血栓素水平升高，然而，需要更多数据来阐明戒烟对尿液中11 - 脱氢血栓素排泄的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/20dca854bcee/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/8031d18a85b7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/45784491f669/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/20dca854bcee/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/8031d18a85b7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/45784491f669/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9902/5977536/20dca854bcee/gr3.jpg

相似文献

1
Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane B.吸烟及戒烟对尿11-脱氢血栓烷B水平的影响
Toxicol Rep. 2018 Apr 19;5:561-567. doi: 10.1016/j.toxrep.2018.04.005. eCollection 2018.
2
Influence of smoking on levels of urinary 8-iso Prostaglandin F2α.吸烟对尿8-异前列腺素F2α水平的影响。
Toxicol Rep. 2018 Nov 20;6:18-25. doi: 10.1016/j.toxrep.2018.11.011. eCollection 2019.
3
Smoking alters thromboxane metabolism in man.吸烟会改变人体中血栓素的代谢。
Biochim Biophys Acta. 1991 Jan 28;1081(2):197-201. doi: 10.1016/0005-2760(91)90026-e.
4
In the dose range of 0.5-2.0 mg/kg, acetylsalicylic acid does not affect prostacyclin production in hypertensive pregnancies.在0.5 - 2.0毫克/千克的剂量范围内，乙酰水杨酸不影响高血压孕妇体内前列环素的产生。
Acta Obstet Gynecol Scand. 1999 Feb;78(2):82-8.
5
Urinary excretion and origin of 11-dehydro-2,3-dinor-thromboxane B2 in man.人体内11-脱氢-2,3-二去甲血栓素B2的尿排泄及来源
Prostaglandins. 1993 May;45(5):401-11. doi: 10.1016/0090-6980(93)90117-p.
6
Relation between tobacco use and urinary excretion of thromboxane A2 and prostacyclin metabolites in young men.年轻男性中烟草使用与血栓素A2和前列环素代谢产物尿排泄之间的关系。
Circulation. 1991 May;83(5):1698-704. doi: 10.1161/01.cir.83.5.1698.
7
Effects of smoking cessation and nicotine substitution on systemic eicosanoid production in man.戒烟及尼古丁替代对人体全身类花生酸生成的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2001 May;363(5):556-61. doi: 10.1007/s002100100398.
8
Smoking and apolipoprotein levels: A meta-analysis of published data.吸烟与载脂蛋白水平：已发表数据的荟萃分析。
Toxicol Rep. 2022 May 17;9:1150-1171. doi: 10.1016/j.toxrep.2022.05.009. eCollection 2022.
9
Excretion of thromboxane metabolites in healthy women after cessation of smoking.戒烟后健康女性血栓素代谢物的排泄情况。
Arterioscler Thromb. 1993 Jun;13(6):777-82. doi: 10.1161/01.atv.13.6.777.
10
Cigarette smoking and urinary excretion of markers for platelet/vessel wall interaction in healthy women.健康女性吸烟与血小板/血管壁相互作用标志物的尿排泄
Clin Sci (Lond). 1991 Jul;81(1):11-5. doi: 10.1042/cs0810011.

引用本文的文献

1
Biomarkers of Exposure and Potential Harm in Two Weeks of Smoking Abstinence: Changes in Biomarkers of Platelet Function, Oxidative Stress, and Inflammation.在两周的戒烟期间暴露和潜在危害的生物标志物：血小板功能、氧化应激和炎症的生物标志物变化。
Int J Mol Sci. 2023 Mar 27;24(7):6286. doi: 10.3390/ijms24076286.
2
Commonalities in Metabolic Reprogramming between Tobacco Use and Oral Cancer.吸烟与口腔癌之间代谢重编程的共同特征。
Int J Environ Res Public Health. 2022 Aug 18;19(16):10261. doi: 10.3390/ijerph191610261.
3
Statistical analysis plan for "A randomised, controlled study to evaluate the effects of switching from cigarette smoking to using a tobacco heating product on health effect indicators in healthy subjects".

本文引用的文献

1
Prognostic value of urinary 11-dehydro-thromboxane B for mortality: A cohort study of stable coronary artery disease patients treated with aspirin.尿 11-去氢血栓烷 B 对死亡率的预测价值：阿司匹林治疗稳定型冠状动脉疾病患者的队列研究。
Catheter Cardiovasc Interv. 2018 Oct 1;92(4):653-658. doi: 10.1002/ccd.27437. Epub 2017 Nov 29.
2
Urinary 11-dehydro-thromboxane B2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease.尿11-脱氢血栓素B2水平与动脉粥样硬化性心血管疾病中的血管炎症及预后相关。
Prostaglandins Other Lipid Mediat. 2018 Jan;134:24-31. doi: 10.1016/j.prostaglandins.2017.11.003. Epub 2017 Nov 16.
3
“A randomised, controlled study to evaluate the effects of switching from cigarette smoking to using a tobacco heating product on health effect indicators in healthy subjects”的统计分析计划
Contemp Clin Trials Commun. 2020 Jan 28;17:100535. doi: 10.1016/j.conctc.2020.100535. eCollection 2020 Mar.
4
Real-World Evidence of Differences in Biomarkers of Exposure to Select Harmful and Potentially Harmful Constituents and Biomarkers of Potential Harm Between Adult E-Vapor Users and Adult Cigarette Smokers.真实世界中电子雾化使用者与成年卷烟吸烟者之间选择的有害和潜在有害成分暴露的生物标志物以及潜在危害的生物标志物的差异证据。
Nicotine Tob Res. 2020 Jun 12;22(7):1114-1122. doi: 10.1093/ntr/ntz185.
Urinary 11-Dehydro-Thromboxane B and Mortality in Patients With Stable Coronary Artery Disease.
稳定型冠状动脉疾病患者的尿11-脱氢血栓素B与死亡率
Am J Cardiol. 2017 Apr 1;119(7):972-977. doi: 10.1016/j.amjcard.2016.12.004. Epub 2017 Jan 5.
4
Urinary 11-Dehydro-Thromboxane B2 as a Predictor of Acute Myocardial Infarction Outcomes: Results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) Study.尿11-脱氢血栓烷B2作为急性心肌梗死预后的预测指标：心肌梗死中的白三烯和血栓烷（LTIMI）研究结果
J Am Heart Assoc. 2016 Aug 1;5(8):e003702. doi: 10.1161/JAHA.116.003702.
5
A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers.一项针对吸烟者和非吸烟者中与心血管疾病相关生物标志物的日本横断面多中心研究。
Biomarkers. 2015;20(6-7):411-21. doi: 10.3109/1354750X.2015.1096303.
6
The heterogeneity statistic I(2) can be biased in small meta-analyses.异质性统计量I(2)在小型荟萃分析中可能存在偏差。
BMC Med Res Methodol. 2015 Apr 14;15:35. doi: 10.1186/s12874-015-0024-z.
7
A cross-sectional analysis of candidate biomarkers of biological effect in smokers, never-smokers and ex-smokers.吸烟者、从不吸烟者和已戒烟者生物效应候选生物标志物的横断面分析。
Biomarkers. 2014 Aug;19(5):356-67. doi: 10.3109/1354750X.2014.912354. Epub 2014 May 22.
8
Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity.脂肪酸和血栓素 A2（TxA2）的生成，在血小板环氧化酶-1 活性缺失的情况下。
Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):428-33. doi: 10.1016/j.numecd.2013.08.012. Epub 2013 Oct 23.
9
Acetylsalicylic acid therapy: influence of metformin use and other variables on urinary 11-dehydrothromboxane B2 levels.乙酰水杨酸治疗：二甲双胍使用和其他变量对尿 11-脱氢血栓烷 B2 水平的影响。
Clin Chim Acta. 2014 Feb 15;429:76-8. doi: 10.1016/j.cca.2013.11.028. Epub 2013 Dec 4.
10
Estimating the decline in excess risk of cerebrovascular disease following quitting smoking--a systematic review based on the negative exponential model.基于负指数模型的戒烟后脑血管病超额风险下降情况的系统评价
Regul Toxicol Pharmacol. 2014 Feb;68(1):85-95. doi: 10.1016/j.yrtph.2013.11.013. Epub 2013 Nov 26.