Köchli O R, Schär G, Beck B, Benz J
Thurgauisches Kantonsspital, Frauenfeld.
Gynakol Geburtshilfliche Rundsch. 1992;32(2):88-91. doi: 10.1159/000271852.
In this study, 43 postmenopausal patients with urogenital complaints such as vaginal dryness, incontinence, or bleeding with intercourse were treated with weekly applications of Orthogynest vaginal estriol suppositories in a new depot form. A marked increase in the vaginal epithelium (A. Schmitt score) and a significant decrease in symptoms due to vaginal atrophy were noted. The depot form allows for decreased dosing frequency, leading to improved compliance. Systemic symptoms, such as hot flashes and emotional lability, were also noted to respond to the Orthogynest suppositories.
在本研究中，43名有泌尿生殖系统症状（如阴道干涩、尿失禁或性交出血）的绝经后患者接受了每周一次的新型长效制剂奥索吉奈斯特阴道雌三醇栓剂治疗。观察到阴道上皮显著增加（A.施密特评分），阴道萎缩引起的症状显著减轻。长效制剂可减少给药频率，从而提高依从性。潮热和情绪不稳定等全身症状对奥索吉奈斯特栓剂也有反应。
