Wilson J T, Hadley D M, Wiedmann K D, Teasdale G M
Department of Psychology, University of Stirling.
Brain Inj. 1992 Sep-Oct;6(5):391-9. doi: 10.3109/02699059209008135.
Forty-three patients with closed head injuries were followed up 5 to 12 months post-injury. Patients had magnetic resonance imaging (MRI) and performed a variety of neuropsychological tests. There were systematic relationships between lesions in different sites: depth of lesions in orbito-frontal regions, frontal regions, and temporal poles were particularly strongly intercorrelated. Depth of lesions in specific sites also correlated with an overall measure of brain damage: the number of areas with lesions present. After correcting for premorbid differences there were significant correlations between lesions in specific sites and scores on three out of five WAIS subtests. Scores on these three subtests also correlated significantly with overall brain damage. In general, hemispheric sites which were significantly related to neuropsychological measures also showed significant intercorrelations among themselves. The findings stress the importance of patterns of lesions in head injury, and emphasize the difficulty of showing differential localization of cerebral function in this population.
43例闭合性颅脑损伤患者在受伤后5至12个月接受了随访。患者接受了磁共振成像（MRI）检查，并进行了各种神经心理学测试。不同部位的损伤之间存在系统性关系：眶额叶区域、额叶区域和颞极的损伤深度之间相关性尤为强烈。特定部位的损伤深度也与脑损伤的总体指标相关：存在损伤的区域数量。在校正病前差异后，特定部位的损伤与韦氏成人智力量表（WAIS）五个子测试中的三个子测试得分之间存在显著相关性。这三个子测试的得分也与总体脑损伤显著相关。一般来说，与神经心理学指标显著相关的半球部位之间也显示出显著的相互相关性。这些发现强调了颅脑损伤中损伤模式的重要性，并强调了在该人群中显示脑功能差异定位的困难。
