Badoer E, McKinley M J, Oldfield B J, McAllen R M
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Vic., Australia.
Brain Res. 1992 Jun 12;582(2):323-8. doi: 10.1016/0006-8993(92)90150-8.
The immunohistochemical detection of the protein, Fos, has been used as an anatomical marker of activated neurons. Three conscious rats were hemorrhaged (4 ml, 20-25% of blood volume) and the distribution of Fos-stained neurons was compared to that in 4 rats which did not have blood removed. In hemorrhaged rats, a higher concentration of Fos-stained neurons was present in the lamina terminalis, particularly the subfornical organ and organum vasculosum of the lamina terminalis, and in the supraoptic and paraventricular nuclei of the hypothalamus. In the medulla, Fos-stained neurons were restricted to the nucleus of the tractus solitarius, area postrema and the ventrolateral medulla. We hypothesize that those neurons are involved in mediating the physiological responses to hemorrhage.
蛋白质Fos的免疫组织化学检测已被用作激活神经元的解剖学标记。对三只清醒大鼠进行出血处理（4毫升，占血容量的20 - 25%），并将Fos染色神经元的分布与4只未失血大鼠的分布进行比较。在出血的大鼠中，终板层，特别是穹窿下器官和终板血管器，以及下丘脑的视上核和室旁核中存在较高浓度的Fos染色神经元。在延髓中，Fos染色神经元局限于孤束核、最后区和延髓腹外侧。我们推测这些神经元参与介导对出血的生理反应。
