Oldfield B J, Bicknell R J, McAllen R M, Weisinger R S, McKinley M J
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Vict., Australia.
Brain Res. 1991 Oct 4;561(1):151-6. doi: 10.1016/0006-8993(91)90760-s.
Expression of Fos, the protein product of c-fos, was studied immunohistochemically in the forebrain of rats infused intravenously with hypertonic solutions. Intravenous 1.5 or 0.75 mol/l NaCl or 1.2 mol/l sucrose in 0.15 mol/l NaCl, but not isotonic 0.15 mol/l NaCl, caused increased Fos expression in the hypothalamic paraventricular and supraoptic nuclei and throughout the lamina terminalis (organum vasculosum laminae terminalis, median preoptic nucleus and subfornical organ). These results show that neurons in the lamina terminalis are activated by physiological increases in plasma tonicity and support an involvement of the lamina terminalis in osmoregulation.
通过免疫组织化学方法，研究了静脉注射高渗溶液的大鼠前脑中c-fos蛋白产物Fos的表达情况。静脉注射1.5或0.75mol/L氯化钠或含于0.15mol/L氯化钠中的1.2mol/L蔗糖溶液（而非等渗的0.15mol/L氯化钠溶液），会导致下丘脑室旁核和视上核以及终板层（终板血管器、视前正中核和穹窿下器官）中Fos表达增加。这些结果表明，终板层中的神经元会因血浆渗透压的生理性升高而被激活，支持终板层参与渗透压调节。
