Goadsby P J
Department of Neurology, Prince Henry Hospital, Little Bay, NSW, Australia.
Brain Res. 1992 Aug 14;588(1):140-3. doi: 10.1016/0006-8993(92)91353-g.
Cortical spreading depression is characterised by a wave of depolarization that moves across the cortex leaving in its wake a state of hyperpolarization. Characteristic changes in cerebral blood flow are also seen and these consist of a wave of hyperemia followed by an oligemia, the latter lasting some hours in some experimental animals including the cat. In this study cerebral blood flow was measured using laser Doppler flowmetry in the anesthetised ventilated cat. Spreading depression was initiated with a pin-prick injury prior to or following administration of U74006F (tirilizad mesylate; 3 mg/kg, ivi) or an identical volume of vehicle. Laser Doppler probes were placed bilaterally and in each case studied both the hyperemic and oligemic phases of spreading depression were preserved after administration of either U74006F or its vehicle. These data suggest that free radical mechanisms have no significant role in mediating the blood flow changes of spreading depression and are consistent with data in the literature of a quantitative using single-point measurements that again U74006F does not affect spreading depression.
皮层扩散性抑制的特征是一波去极化波穿过皮层，随后留下超极化状态。还可见到脑血流的特征性变化，这些变化包括一波充血，随后是缺血，在包括猫在内的一些实验动物中，后者持续数小时。在本研究中，使用激光多普勒血流仪在麻醉通气的猫中测量脑血流。在给予U74006F（甲磺酰替拉扎特；3mg/kg，静脉注射）或相同体积的载体之前或之后，用针刺损伤引发扩散性抑制。双侧放置激光多普勒探头，在每种情况下，给予U74006F或其载体后，均保留了扩散性抑制的充血期和缺血期。这些数据表明，自由基机制在介导扩散性抑制的血流变化中没有显著作用，并且与文献中使用单点测量的定量数据一致，即U74006F不影响扩散性抑制。
