Duckrow R B, Beard D C
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Brain Res. 1992 Feb 14;572(1-2):296-9. doi: 10.1016/0006-8993(92)90488-u.
The 21-aminosteroid antioxidant tirilazad mesylate (U-74006F) blocks the delayed hypoperfusion associated with spreading cortical depression (SCD) in anesthetized rats. Because the resting vascular tone influences the blood flow response to SCD, the effect of this drug was reassessed in awake rats. In this state, tirilazad mesylate did not eliminate cerebral hypoperfusion following SCD. Oxygen radical-induced lipid peroxidation may not mediate cerebral hypoperfusion after SCD in awake rats.
21-氨基类固醇抗氧化剂甲磺酸替拉扎特（U-74006F）可阻断麻醉大鼠中与扩展性皮质抑制（SCD）相关的迟发性脑灌注不足。由于静息血管张力会影响对SCD的血流反应，因此在清醒大鼠中重新评估了该药物的作用。在这种状态下，甲磺酸替拉扎特并不能消除SCD后的脑灌注不足。氧自由基诱导的脂质过氧化可能不是清醒大鼠SCD后脑灌注不足的介导因素。
