Devitt J E, To T, Miller A B
Department of Surgery, Ottawa Civic Hospital, Ont.
CMAJ. 1992 Jul 1;147(1):45-9.
To study the occurrence of breast cancer in women with breast cysts.
Prospective follow-up study.
Office surgical practice.
All 742 women referred to the practice with breast cysts diagnosed by means of aspiration or, occasionally, biopsy between 1969 and 1985.
The incidence of breast cancer and the number of years between diagnosis of breast cyst and diagnosis of cancer. The observed number of cases of breast cancer was compared with the expected number, calculated from Ontario rates of breast cancer.
Fifteen of the women died but did not have breast cancer. No follow-up information was available for five women. Another 38 were lost to follow-up; they did not have breast cancer at the last contact, after 2 to 17 years of follow-up. These patients were withdrawn from the study in the year in which they died or were last observed. By 1990, 34 (5%) of the women had breast cancer. The overall ratio of observed:expected cases of cancer was 3.04 (95% confidence interval 2.09 to 4.28). Breast cancer developed after 7.5 years, but the average length of follow-up was only 10.1 years. Only 3.8% of 374 women after 10 years and 5.4% of 141 women after 15 years had breast cancer.
Women who have a gross breast cyst are at moderately increased risk of breast cancer, which usually develops only after many years.
研究患有乳腺囊肿的女性患乳腺癌的情况。
前瞻性随访研究。
门诊外科诊所。
1969年至1985年间因乳腺囊肿前来该诊所就诊，经穿刺抽吸或偶尔经活检确诊的所有742名女性。
乳腺癌的发病率以及乳腺囊肿诊断至癌症诊断之间的年数。将观察到的乳腺癌病例数与根据安大略省乳腺癌发病率计算出的预期病例数进行比较。
15名女性死亡，但未患乳腺癌。5名女性无随访信息。另有38名失访；在随访2至17年后的最后一次接触时，她们未患乳腺癌。这些患者在其死亡或最后一次被观察到的年份退出研究。到1990年，34名（5%）女性患乳腺癌。观察到的癌症病例与预期病例的总体比例为3.04（95%置信区间2.09至4.28）。乳腺癌在7.5年后发生，但平均随访时间仅为10.1年。10年后，374名女性中只有3.8%患乳腺癌，15年后，141名女性中只有5.4%患乳腺癌。
患有明显乳腺囊肿的女性患乳腺癌的风险适度增加，且通常在多年后才会发生。
