Hutchinson W B, Thomas D B, Hamlin W B, Roth G J, Peterson A V, Williams B
J Natl Cancer Inst. 1980 Jul;65(1):13-20.
A group of 1,489 white women were treated in a private surgery practice from 1940 through 1975 for biopsy-proved benign breast disease, and 1,441 were followed through 1976 for the development of breast cancer. Average duration of follow-up was 12.9 years for a total of 18,617 person-years of observation. Information was collected from a set of questions devised in 1941 and asked of all subjects at the time of their initial office visit, follow-up interview conducted in 1976, and a standardized histology review of the slides from the initial benign lesions and the subsequent cancers. The current pathology review indicated that 66 of the women developed breast cancer. The incidence rate was 3.55 per 1,000 person-years, which is 2.10 times that of the general population. When multiple disease types and other variables were controlled for, excess risk of breast cancer was related to the presence of fibrocystic disease. In women with fibrocystic disease, excess risk was particularly related to the presence of epithelial hyperplasia and/or papias not related to the presence of fibroadenoma alone, but it was related to the presence of fibroadenoma in women with concomitant fibrocystic disease. The excess risk was also directly related to the estimated size of the initial benign mass and was greater for women with bilateral than with unilateral benign lesions.
1940年至1975年期间，在一家私人外科诊所对1489名白人女性进行了活检证实的良性乳腺疾病治疗，其中1441人在1976年接受了乳腺癌发病随访。平均随访时间为12.9年，总观察人年数为18617人年。信息收集自1941年设计的一组问题，并在所有受试者首次就诊时、1976年进行的随访访谈以及对初始良性病变和后续癌症的切片进行标准化组织学检查时询问。目前的病理检查表明，有66名女性患了乳腺癌。发病率为每1000人年3.55例，是普通人群的2.10倍。当控制多种疾病类型和其他变量时，乳腺癌的额外风险与纤维囊性疾病的存在有关。在患有纤维囊性疾病的女性中，额外风险尤其与上皮增生和/或乳头瘤的存在有关，不仅仅与纤维腺瘤的存在有关，但在伴有纤维囊性疾病的女性中，额外风险与纤维腺瘤的存在有关。额外风险也与初始良性肿块的估计大小直接相关，双侧良性病变女性的额外风险高于单侧良性病变女性。
