NOWELL P C, COLE L J
Science. 1963 Aug 9;141(3580):524-6. doi: 10.1126/science.141.3580.524.
A marked difference was observed between the effectiveness of high and low dose rates of ionizing radiation in producing persistent chromosome aberrations in the marrow cells of mice. Clones of cells with chromosome abnormalities were present in the marrow of all the mice previously exposed to single or fractionated doses of x-rays given at a rate of 30 rad/min. The frequency of chromosome aberrations in these mice varied from 14 to 72 percent of the cells exdmined. By contrast, none of the mice exposed to continuous gamma radiation at a low dose rate (1.45 rad/hour) showed definite clones of abnormal marrow cells, and the frequency of persistent chromosome aberrations varied from zero to 8 percent in this group.
在产生小鼠骨髓细胞持续性染色体畸变方面，观察到高剂量率和低剂量率电离辐射的有效性存在显著差异。先前以30拉德/分钟的速率接受单次或分次X射线照射的所有小鼠的骨髓中都存在具有染色体异常的细胞克隆。这些小鼠中染色体畸变的频率在检测细胞的14%至72%之间变化。相比之下，以低剂量率（1.45拉德/小时）接受连续伽马辐射的小鼠中没有一只显示出明确的异常骨髓细胞克隆，并且该组中持续性染色体畸变的频率从零到8%不等。
