Gemmill R M, Mendez M J, Dougherty C M, Paulien S, Liao M, Mitchell D, Jankowski S A, Trent J M, Berger C, Sandberg A A
Eleanor Roosevelt Institute, Denver, Colorado 80206.
Cancer Genet Cytogenet. 1992 Sep;62(2):166-70. doi: 10.1016/0165-4608(92)90257-9.
Cytogenetic analysis of liposarcomas has demonstrated that translocation (12;16) (q13.3;p11.2) is characteristic of the myxoid subtype of this adipose tissue tumor. Our previous results suggested that the GLI gene is close to the translocation breakpoint on chromosome 12. We now describe a yeast artificial chromosome (YAC) that contains GLI and spans the chromosome 12 region involved in the t(12;16) breakpoint. This clone will permit rapid definition of the genetic region surrounding the breakpoint and allow isolation of the gene presumably affected by the translocation.
脂肪肉瘤的细胞遗传学分析表明，易位（12；16）（q13.3；p11.2）是这种脂肪组织肿瘤黏液样亚型的特征。我们之前的结果提示，GLI基因靠近12号染色体上的易位断点。我们现在描述一个包含GLI基因并跨越12号染色体上涉及t（12；16）断点区域的酵母人工染色体（YAC）。这个克隆将有助于快速确定断点周围的遗传区域，并允许分离可能受易位影响的基因。
