Ezura M, Fujiwara S, Nose M, Yoshimoto T, Kyogoku M
Division of Neurosurgery, School of Medicine, Tohoku University, Sendai, Japan.
Childs Nerv Syst. 1992 Aug;8(5):263-7. doi: 10.1007/BF00300793.
To examine the possible role of immune complex-mediated reactions in moyamoya disease, a novel experimental system using a serum sickness vasculitis model combined with intracisternal administration of antibodies or antigens was developed. Twenty-eight male Japanese white rabbits were divided into four experimental groups. Group I was treated twice with intravenous injections of heterologous serum. In group II, intracisternal administration of antibodies or antigens was combined with the second injection of serum. Group III received a single intravenous injection of antigens simultaneously with intracisternal administration of antibodies. Group IV was a technical control group. Cerebral arteritis, although likely in the initial process, was induced only in groups II and III. This study suggests that the cerebral arteries rarely develop arteritis in a serum sickness model alone. The cerebral arteries may require additional intracisternal administration of antibodies or antigens to induce in situ deposition of immune complexes around them.
为研究免疫复合物介导的反应在烟雾病中的可能作用，开发了一种新的实验系统，该系统采用血清病血管炎模型并结合脑池内注射抗体或抗原。28只雄性日本白兔被分为四个实验组。第一组静脉注射异种血清两次。第二组在第二次注射血清的同时进行脑池内抗体或抗原注射。第三组在脑池内注射抗体的同时静脉注射一次抗原。第四组为技术对照组。尽管在初始过程中可能发生，但仅在第二组和第三组中诱导出了脑动脉炎。该研究表明，仅在血清病模型中脑动脉很少发生动脉炎。脑动脉可能需要额外的脑池内抗体或抗原注射，以诱导免疫复合物在其周围原位沉积。
