Nzerue M C
Department of Internal Medicine, University of Nigeria Medical School, Enugu.
Cent Afr J Med. 1992 Jun;38(6):247-52.
Lassa fever is an acute viral illness which causes consideration morbidity and mortality in the West African subregion. Recent studies have revealed that platelet and endothelial dysfunction might play a central role in the pathophysiology of this disease. Guidelines for the management of cases of the disease have recently been revised by the Centres for Disease Control, recommending care in local hospitals with use of meticulous barrier nursing techniques. This article reviews the epidemiology, immunology, pathogenesis and pathology, and current algorithms for prevention and therapy.
拉沙热是一种急性病毒性疾病，在西非次区域可导致较高的发病率和死亡率。最近的研究表明，血小板和内皮功能障碍可能在该疾病的病理生理学中起核心作用。美国疾病控制中心最近修订了该疾病的病例管理指南，建议在当地医院采用严格的屏障护理技术进行治疗。本文综述了其流行病学、免疫学、发病机制和病理学，以及当前的预防和治疗方案。
