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[当归对慢性阻塞性肺疾病肺动脉高压的短期影响及机制]

[Short-term effect and the mechanism of radix Angelicae on pulmonary hypertension in chronic obstructive pulmonary disease].

作者信息

Zheng L

机构信息

Research Department of Respiratory Diseases of Affilated Tongji, Hospital to Tongji, Medical University, Wuhan.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 1992 Apr;15(2):95-7, 127.

PMID:1394602
Abstract

The changes of hemodynamics, hemorheology and blood gas were investigated in 28 stable COPD patients with pulmonary hypertension after short-term treatment by Radix Angelicae. The level of TXA2, PGI2 were measured in 10 of the 28 patients before and after treatment. The results show that Radix Angelicae produced significant improvement on pulmonary hypertension, blood viscosity, hematocrit and the level of TXA2 decreased significantly. But the blood gas, blood pressure and the level of PGI2 remained unchanged in all of the patients.

摘要

对28例稳定期慢性阻塞性肺疾病(COPD)合并肺动脉高压患者短期服用当归进行治疗,观察其血液动力学、血液流变学及血气的变化。并对其中10例患者治疗前后血栓素A2(TXA2)、前列环素(PGI2)水平进行测定。结果显示,当归对肺动脉高压、血液黏度、红细胞压积有明显改善作用,TXA2水平明显降低。但所有患者的血气、血压及PGI2水平均无变化。

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