Veldhuis J D, Johnson M L, Lizarralde G, Iranmanesh A
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.
Chronobiol Int. 1992 Oct;9(5):371-9. doi: 10.3109/07420529209064549.
Because of confounding effects of subject-specific and hormone-specific metabolic clearance, the nature of anterior pituitary secretory events in vivo is difficult to ascertain. We review an approach to this problem, in which deconvolution analysis is used to dissect the underlying secretory behavior of an endocrine gland quantitatively from available serial plasma hormone concentration measurements assuming one- or two-compartment elimination kinetics. This analytical tool allows one to ask the following physiological questions: (a) does the anterior pituitary gland secrete exclusively in randomly dispersed bursts, and/or does a tonic (constitutive) mode of interburst hormone secretion exist? and (b) what secretory mechanisms generate the circadian or nyctohemeral rhythms in blood concentrations of pituitary hormones?(ABSTRACT TRUNCATED AT 250 WORDS)
由于个体特异性和激素特异性代谢清除的混杂效应，体内垂体前叶分泌事件的本质难以确定。我们回顾了一种解决该问题的方法，其中反卷积分析用于从可用的系列血浆激素浓度测量值中，假定采用单室或双室消除动力学，定量剖析内分泌腺的潜在分泌行为。这种分析工具使人们能够提出以下生理学问题：(a)垂体前叶是否仅以随机分散的脉冲形式分泌，和/或脉冲间激素分泌是否存在一种持续性（组成性）模式？以及(b)哪些分泌机制产生垂体激素血浓度的昼夜节律或日节律？（摘要截选于250词）
