垂体前叶激素分泌的昼夜节律：地塞米松的影响。

Circadian rhythms of anterior pituitary hormone secretion: effects of dexamethasone.

作者信息

Tolis G, Banovac K, McKenzie J M, Guyda H

出版信息

J Endocrinol Invest. 1979 Oct-Dec;2(4):433-6. doi: 10.1007/BF03349346.

Abstract

Circadian rhythms of hormone secretion are by now well recognized but there are limited data available to compare such rhythms of multiple hormones in individual subjects. Therefore concentrations of serum thyrotropin (TSH), cortisol, growth hormone (GH), triiodothyronine (T3) and prolactin (PRL) were determined in blood samples from six healthy males over periods of 24 hours. A circadian periodicity was identified for cortisol, GH, PRL and TSH; maximum concentrations for TSH and PRL occurred at dissimilar times, namely respectively before and after the GH peak. Maximum TSH coincided with nadir values forplasma cortisol. Dexamethasone administration (3 mg over 36 hours) lowered serum T3 concentration and abolished TSH periodicity without affecting the PRL rhythm. These data suggest that a) nocturnal TSH and PRL maximum levels do not have common mediation; b) there may be an inverse relationship between cortisol and TSH, and c) glucocorticoids at low doses preferentially affect secretion of thyrotropin.

摘要

激素分泌的昼夜节律如今已得到充分认识，但关于个体受试者多种激素此类节律比较的数据有限。因此，对6名健康男性在24小时内采集的血样中血清促甲状腺激素（TSH）、皮质醇、生长激素（GH）、三碘甲状腺原氨酸（T3）和催乳素（PRL）的浓度进行了测定。已确定皮质醇、GH、PRL和TSH存在昼夜周期性；TSH和PRL的最高浓度出现在不同时间，分别在GH峰值之前和之后。TSH最高值与血浆皮质醇的最低值同时出现。给予地塞米松（36小时内3毫克）可降低血清T3浓度并消除TSH的周期性，而不影响PRL节律。这些数据表明：a）夜间TSH和PRL的最高水平没有共同的调节机制；b）皮质醇与TSH之间可能存在负相关关系；c）低剂量糖皮质激素优先影响促甲状腺激素的分泌。