Kobayashi N, Asano T, Kitahori J, Shimada K, Kubodera N, Watanabe H
Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
Chem Pharm Bull (Tokyo). 1992 Jun;40(6):1520-2. doi: 10.1248/cpb.40.1520.
22-Oxacalcitriol 3-hemiglutarate, a haptenic derivative of 22-oxacalcitriol, was synthesized to obtain a specific antibody for use in radioimmunoassay. Three antisera were elicited in rabbits against the hapten conjugated with bovine serum albumin, and their specificity was examined by cross-reaction study. One of the antisera was found to be satisfactorily specific, and expected to provide a radioimmunoassay useful for the pharmacokinetic study of 22-oxacalcitriol.
