赖氨酸缺乏与宿主对炭疽的抵抗力
Lysine deficiency and host resistance to anthrax.
作者信息
GRAY I
出版信息
J Exp Med. 1963 Mar 1;117(3):497-508. doi: 10.1084/jem.117.3.497.
Abstract
- Lysine deficiency has been produced in rats by placing the weanling animals on an experimental diet in which gluten replaced the casein of the control diet. Both diets were complete in all other known requirements. 2. The resistance of the deficient animals to a subcutaneous challenge of several concentrations of B. anthracis spores, was decreased. Deaths occurred within 2 days post inoculation. 3. When lysine was added to the gluten diet to bring the total concentration to that of the control diet, the growth rate of the animals was maintained but a decrease in resistance remained, although not as great as on the gluten diet. 4. Changes in the tissues associated with lysine deficiency are reported. 5. It is not unreasonable to state that within the time frame of our experiments, the decreased ability of the RES of the host to clear the invading organism from the tissues and subsequently to break down the organism is a major factor of the decreased resistance of the lysine-deficient rats to anthrax.
摘要
- 通过给断奶大鼠喂食以麸质替代对照饮食中酪蛋白的实验性饮食，造成了大鼠赖氨酸缺乏。两种饮食在所有其他已知必需营养成分上均是完整的。2. 缺乏赖氨酸的动物对皮下注射几种浓度的炭疽芽孢杆菌孢子的抵抗力下降。接种后2天内出现死亡。3. 当向麸质饮食中添加赖氨酸以使总浓度达到对照饮食的水平时，动物的生长速度得以维持，但抵抗力仍有下降，尽管不如仅喂食麸质饮食时那么严重。4. 报告了与赖氨酸缺乏相关的组织变化。5. 可以合理地指出，在我们的实验时间范围内，宿主网状内皮系统清除组织中入侵生物体并随后分解该生物体的能力下降，是赖氨酸缺乏的大鼠对炭疽抵抗力下降的一个主要因素。
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