肿瘤坏死因子可增强石棉诱导的人多形核白细胞（PMN）产生活性氧代谢产物。
Tumour necrosis factor enhances the asbestos-induced production of reactive oxygen metabolites by human polymorphonuclear leucocytes (PMN).
作者信息
Klockars M, Savolainen H
机构信息
Institute of Occupational Health, Helsinki, Finland.
出版信息
Clin Exp Immunol. 1992 Oct;90(1):68-71. doi: 10.1111/j.1365-2249.1992.tb05833.x.
Abstract
We studied the effect of recombinant tumour necrosis factor-alpha (TNF-alpha) on the production of reactive oxygen metabolites (ROM) by human PMN exposed in vitro to chrysotile and crocidolite asbestos fibres, quartz dusts and opsonized zymosan. TNF caused a significant increase in ROM release by PMN, and significantly and dose-dependently amplified the ROM production induced by asbestos fibres. The amplification of ROM production by TNF can be of crucial importance in the process of lung inflammation and fibrogenesis in pneumoconioses.
摘要
我们研究了重组肿瘤坏死因子-α（TNF-α）对体外暴露于温石棉、青石棉纤维、石英粉尘和调理酵母聚糖的人中性粒细胞产生活性氧代谢产物（ROM）的影响。TNF导致中性粒细胞释放的ROM显著增加，并显著且剂量依赖性地放大了石棉纤维诱导的ROM产生。TNF对ROM产生的放大在尘肺病的肺部炎症和纤维化过程中可能至关重要。
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