Hüppe D, Tromm A, Langhorst H, May B
Abteilung für Gastroenterologie und Hepatologie, Berufsgenossenschaftliche Krankenanstalten Bergmannsheil, Klinikum der Ruhr-Universität Bochum.
Dtsch Med Wochenschr. 1992 Oct 9;117(41):1550-5. doi: 10.1055/s-2008-1062476.
In 124 patients with Crohn's disease (69 women, 55 men; mean age 33.7 [11-66] years) and 53 with ulcerative colitis (30 women, 23 men; mean age 36.2 [19-74] years) the incidence of lactose intolerance, as measured by the H2 breath test and blood sugar concentration, was determined prospectively. To exclude abnormal bacterial colonization of the small intestine or rapid small-intestine transit after partial resection of the small intestine as a cause of lactose intolerance, the oro-caecal transit time for lactulose (H2 breath test) was measured. While 21 of 124 patients with Crohn's disease (16.9%) had the expected incidence of lactose intolerance, this was present in only 2 of 53 patients with ulcerative colitis (3.8%; P < 0.05). The lactose intolerance was independent of the site of any inflammatory changes, disease activity and extent of small-intestine resection. Oro-caecal transit time for lactose was similar for all patients. There was no lactose intolerance in two patients with abnormal small-intestinal bacterial colonization.--Because of their considerable diagnostic and prognostic significance, tests for lactose intolerance should be performed routinely in all cases of Crohn's disease or ulcerative colitis.
对124例克罗恩病患者（69例女性，55例男性；平均年龄33.7[11 - 66]岁）和53例溃疡性结肠炎患者（30例女性，23例男性；平均年龄36.2[19 - 74]岁），通过氢呼气试验和血糖浓度前瞻性地测定乳糖不耐受的发生率。为排除小肠细菌定植异常或小肠部分切除术后小肠快速转运作为乳糖不耐受的原因，测量了乳果糖的口盲肠转运时间（氢呼气试验）。124例克罗恩病患者中有21例（16.9%）出现预期的乳糖不耐受发生率，而53例溃疡性结肠炎患者中只有2例（3.8%；P<0.05）出现乳糖不耐受。乳糖不耐受与任何炎症改变的部位、疾病活动度及小肠切除范围无关。所有患者的乳糖口盲肠转运时间相似。两名小肠细菌定植异常的患者未出现乳糖不耐受。——鉴于乳糖不耐受检测具有重要的诊断和预后意义，应在所有克罗恩病或溃疡性结肠炎病例中常规进行乳糖不耐受检测。
